Alector Inc. cuts its workforce by nearly 50% following the failure of its dementia drug trial, signalling challenges in the biotech sector and the drug development process.

San Francisco settled with online tobacco retailers for nearly $3 million due to illegal sales of flavored nicotine products, enforcing strict health laws and protocols to prevent future violations.

Netflix shares dropped 6% due to an earnings miss caused by a Brazilian tax dispute, ending its profit streak, with $2.5 billion in profit and $11.5 billion in revenue for the quarter.

Downtown is booming again thanks to Dreamforce — but the city’s biggest tech event comes with a storm of politics, backlash, and billionaire drama.

The Port of Oakland saw reduced cargo volumes in September 2025 due to shifting trade patterns, despite maintaining operational efficiency and resilience.

Nordstrom reopens in San Francisco's Upper Fillmore District with a Nordstrom Local service hub offering pickups, returns, and other services, amid varying local reception.

Uniqlo plans to open a flagship store on Market Street in San Francisco, marking a return after closing its Union Square location in 2021. The move is part of the brand's U.S. expansion.

The San Francisco Planning Commission blocked Club Pilates from opening in the Mission District due to community opposition, fearing it would undermine the area's unique character.

California prosecutors say Sephora was throwing away hazardous waste in stores from San Francisco's Powell Street to Santana Row in San Jose and beyond. The beauty giant's settlement reveals just how much expired makeup and battery-powered tools were ending up in landfills across the state.

The Lucky grocery store in San Francisco's Bayview District is set to close on November 1, leaving the community, known as a food desert, without a key source of fresh groceries and prompting concerns over corporate commitment to the area.

Charles Schwab Corp. is expanding its branch network and workforce, opening a new branch in San Francisco's Mission Bay and hiring over 40 Bay Area employees as part of a nationwide growth initiative.

Pop Mart's new San Francisco store in Union Square is attracting fans of Labubu figures, adding excitement to the retail district with its unique collectibles and plush toys.

Chrome Holding Co. agrees to acquire Lemonaid Health, a telemedicine company facing bankruptcy, via a deal with Bambu Ventures and Innova Capital Partners.