An early‑morning shooting at Bikers Corner Cocktail Lounge in Jeff‑Vander‑Lou left one man dead; police are searching for a suspect.

WashU neurologist Tim Miller co‑led long‑term tofersen trials that show stabilization or improvement for some SOD1‑ALS patients — a milestone for a rare genetic form. The result reflects decades of antisense work at WashU.

Danielle Uskiwich, a St. Charles High attendance secretary, died after a head injury at Pointfest. Her family honored her through organ donation and an honor walk.

Local label Retta Jane is seeking city approval to open a combined boutique and wine bar in downtown Clayton.

A 6-year-old was seriously injured in an accidental shooting at a Glasgow Village home; St. Louis County police say the firearm’s owner has been charged.

A man was fatally shot near the 1400 block of North 13th Street in Columbus Square; homicide detectives are on the scene and the investigation is active.

A wrong‑way pickup hit a semi on I‑270 near Lindbergh early May 24; one driver was taken to Mercy Hospital St. Louis with minor injuries.

St. Louis County police are investigating Islamophobic graffiti found in South County this weekend; no injuries were reported and investigators are seeking tips.

A botched soil reuse from the Market at Olive has left Ruth Park's driving range closed while University City officials evaluate fixes.

Crews will begin debris removal at the Crunden‑Martin warehouses next week, months after the five‑alarm blaze that gutted key buildings in the Gateway South footprint.

Missouri AG says the owner of JK Exteriors faces charges after dozens of homeowners, including tornado survivors, reportedly lost more than $131,000. The warrants name multiple unfinished jobs and missing refunds.

A Chesterfield mover was arrested after nearly $90,000 in jewelry disappeared from two homes, with investigators tracing some items to a pawn shop.

Broadway Ford Truck Sales has filed Chapter 11 after expansion plans left it owing millions and naming hundreds of creditors.