A two-vehicle crash in Sugarcreek Borough left a 34-year-old woman dead and a 39-year-old driver charged with homicide-by-vehicle while driving under the influence.

Pitt researchers identified hypothalamic enzymes FAK and PYK2 that restored leptin response in mice, producing major fat loss while preserving muscle — a potential new drug target.

Flyers with personal details and antisemitic language were left outside a North Side home, the latest in a years-long pattern that included an Israeli flag being slashed. Police have identified a suspect and filed charges.

A fire at Ross Park Mall extinguished by firefighters caused no injuries and the mall reopened the same day post air quality checks. A fire truck en route collided with a car, leading to three firefighters being hospitalized.

The National Weather Service discusses the end of snow squalls, ongoing cold wind chills, and the potential for additional snowfall and extreme cold in parts of Pennsylvania, Ohio, and West Virginia. Warming trends may lead to flooding.

Pittsburgh police evacuated a person from a house fire on Knox Avenue; firefighters controlled the blaze, and no injuries were reported. The cause is under investigation.

A naked man, Darnell Howell, armed with knives, went on a rampage at Check Eye Group in Belle Vernon, causing damage and leading to his arrest on multiple charges.

Two people were hospitalized after a head-on collision on the Fort Duquesne Bridge in Pittsburgh; lanes on I-279 were closed for cleanup. The cause is unknown.

A woman was critically injured after being hit by a PRT bus in Oakland, Pittsburgh. Emergency services responded, and the intersection was closed for investigation. Witnesses described the scene and the woman was taken to the hospital.

An explosion at the Langeloth Metallurgical Plant in Pennsylvania injured four. Authorities assured no hazardous substances were released, as the DEP and EPA investigate the cause.

Gary Cawley was arrested after a chase on the Allegheny River, facing charges including burglary and trespassing at a former VA building in Pittsburgh.

The Church Arcade, located in a repurposed church in Duquesne, is opening with a flat fee model for unlimited gameplay, offering nostalgia with vintage games.

Pittsburgh's trash and recycling pickup is delayed by two days due to snow removal efforts by the Department of Public Works’ Environmental Services.