Interim data show a single infusion of a PCSK9 base editor sharply lowered LDL in an early trial, while Cleveland researchers link low nitric oxide to altered gene splicing in Alzheimer’s. Clinicians warned that supplements aren’t regulated like drugs and can carry risks.

Seattle‑based Brighton Jones has opened an office in Beachwood and tapped local advisor Mitchell Kotheimer to lead its Cleveland push.

A two-vehicle crash at SR 21 and SR 212 in Bethlehem Township on Memorial Day killed a 28-year-old Coshocton man and injured two others.

School and city leaders say county "piggyback" tax breaks pulled millions from Lorain classrooms; commissioners paused a decision and will revisit it on June 2.

A stolen car flipped near West 28th and Detroit Avenue after a shooting; four teens were arrested and one 15‑year‑old was hospitalized. Police recovered two guns and are asking for tips.

A 378-unit complex in downtown Cuyahoga Falls is being marketed to investors, putting nearly 400 workforce-housing doors on the block.

One person is in custody after early-morning gunfire in Mayfield Heights; police say there were no injuries and the probe is ongoing.

A new Trevor Project survey finds 36% of LGBTQ+ young people seriously considered suicide last year, and many who wanted help couldn't get it.

A Northeast Ohio chain beat national brands to claim USA TODAY's top sports bar honor. The award recognizes Winking Lizard's beer list and game-day vibe.

House Bill 433 would redraw Ohio’s amusement‑ride fee map. Small inflatable operators warn the changes could be costly while sponsors say they make fees fairer.

A passerby discovered a deceased person on the sidewalk near East 61st and St. Clair, and police say the death is under investigation.

Family-run Melted Wings Winery opens a tasting room in Old Brooklyn with Greek-rooted winemaking, limited Thursday–Saturday hours and a cellar-style vibe. Small batches and a wine slushy are on the menu.

Emergency crews treated and transported a teenage male after a reported self-inflicted gunshot in Garfield Heights; authorities are investigating and details remain limited.