Phoenix

Phoenix Greenlights 260-Room Hilton Across From Mayo Clinic

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Published on April 09, 2026
Phoenix Greenlights 260-Room Hilton Across From Mayo ClinicSource: Google Street View

A new Hilton hotel is officially headed to North Phoenix, with the City Council signing off on a roughly 260-room project across from Mayo Clinic's rapidly growing campus.

The hotel is planned for the southeast corner of 64th Street and Mayo Boulevard and is pitched as a landing place for hospital visitors, extended-stay patients, and business travelers flowing into the fast-growing Desert Ridge corridor.

What the council approved

On April 8, the Phoenix City Council approved zoning changes and a planned-unit-development amendment that developers said they needed to move the project forward, according to the Phoenix Business Journal. The outlet reported that the approval clears the way for the development team to pursue permits and finalize design work for the hotel.

Project details and who is building it

Plaza Companies and Fayth Hospitality are listed as the development team behind the project, which is planned as a dual-branded Hilton on an 8.15-acre parcel, according to Plaza Companies. The city's planning packet describes a six-story hotel with roughly 257 guestrooms, ground-floor amenities and surface parking, according to City of Phoenix documents.

Why it matters for the Mayo corridor

City of Phoenix Community and Economic Development Director Christine Mackay called the project "a significant milestone" for the area in a statement to Plaza Companies. The new hotel is arriving as Mayo Clinic pursues a multibillion-dollar expansion of its Phoenix campus, a buildout estimated at $1.9 billion that is expected to add clinical space and patient capacity, according to The Real Deal.

Next steps and what is on the clock

Developers say shovels will not hit the dirt until they secure final brand approvals and complete design work, and the city's planning packet does not provide a firm construction start date. The April 8 council vote advances the rezoning and PUD changes the team needs to begin permit applications and design review, according to City of Phoenix documents.

Phoenix-Real Estate & Development