After a failed flu trial, Marianne De Backer closed labs, cut staff and struck licensing deals that refocused San Francisco’s Vir on hepatitis and cancer. The result is a leaner company with big‑pharma partners.

A three-alarm fire at a Whipple Avenue apartment building sent four people to hospital and left 23 residents displaced as investigators probe the cause.

A UCSF physician lays out a 'primary care common fund' to make front‑line care universal in California, but federal waivers and politics remain major obstacles.

Yosemite’s no‑ticket summer collided with an early spike in rattlesnake bites, turning holiday crowds into a safety headache for parkgoers.

SFFD and CHP crews rescued a hiker who fell roughly 70–100 feet near the Presidio's West Coast Memorial. The person was treated on scene and transported to an area hospital.

An Alcatraz City Cruises ferry struck Pier 31 while docking, shattering windows and jolting riders; the operator says there are no reported injuries and an investigation is underway.

Cool, cloudy Tuesday morning in San Jose; mostly sunny but blustery this afternoon with gusts and hazardous marine conditions through Wednesday.

Gusty WNW winds will pick up Tuesday with gusts through the afternoon. Pacific beaches are under a Beach Hazards Statement — avoid jetties and secure outdoor items.

A man who climbed onto a Sonoma County Transit bus near Santa Rosa Junior College stayed atop the vehicle for nearly 10 hours before coming down and being booked, police said.

Gov. Gavin Newsom named former CFPB director Rohit Chopra to lead California’s new consumer agency — a move that strengthens state enforcement and carries national political weight.

Menlo Park officers used a GPS tag to track a dark sedan to Berkeley; juveniles were arrested and the driver was booked on a reckless‑evasion charge.

A longtime Broadcom engineer says she was labeled "difficult" and fired after 26 years; she filed suit in Santa Clara County alleging gender-based harassment and reputational harm.

Federal investigators say a former TIBCO benefits director and a partner siphoned $823,299 from employee benefit accounts over several years. Both have been arrested and face dozens of felony counts.