Pitt researchers identified hypothalamic enzymes FAK and PYK2 that restored leptin response in mice, producing major fat loss while preserving muscle — a potential new drug target.

A toddler died after being run over by a tractor in Leola. East Lampeter police say the incident is under investigation.

Police broke up an underage party at a North Side Airbnb. Two adults were charged and officers said they found guns and drugs at the rental.

Flyers with personal details and antisemitic language were left outside a North Side home, the latest in a years-long pattern that included an Israeli flag being slashed. Police have identified a suspect and filed charges.

Opening statements began Monday in Westmoreland County for Melissa Fox-Beacom and Matthew Bates in the death of Alice Robson; prosecutors say an alleged shooter will testify.

Court filings say a woman had a 0.15% BAC when her SUV mounted a curb and struck a 12-year-old student and a staff member outside Westinghouse Academy.

The National Weather Service forecasts variable weather in Pittsburgh, with a shift from warm to cold and possible rain, light snow, and freezing drizzle. Travel impacts are minor, but conditions may change quickly.

A fire at Ross Park Mall extinguished by firefighters caused no injuries and the mall reopened the same day post air quality checks. A fire truck en route collided with a car, leading to three firefighters being hospitalized.

Pittsburgh weather remains stable; a Cold Weather Advisory in place until 10 AM. Temperatures to rise Tuesday but dip again later. Aviation forecasts clear VFR conditions. Light rain/snow possible Tuesday night.

An 83-year-old man with early-stage dementia was found stabbed in a Pittsburgh home after a reported break-in. The homeowner is being questioned; the investigation is ongoing.

The National Weather Service discusses the end of snow squalls, ongoing cold wind chills, and the potential for additional snowfall and extreme cold in parts of Pennsylvania, Ohio, and West Virginia. Warming trends may lead to flooding.

A Wilmerding man was arrested for child pornography possession after a cyber tip from Dropbox led to a search warrant and the seizure of explicit materials from his home.

An 18-vehicle crash on I-79 in Butler County led to one death, a highway closure, and a 45 mph speed limit due to winter conditions. The investigation is ongoing.