Phoenix

Cardinals' Marvin Harrison Jr. Ruled Out Against 49ers Following Appendicitis Surgery

AI Assisted Icon
Published on November 13, 2025
Cardinals' Marvin Harrison Jr. Ruled Out Against 49ers Following Appendicitis SurgerySource: Alexander Jonesi, CC BY-SA 2.0, via Wikimedia Commons

The Arizona Cardinals' wide receiver corps has taken another hit as Marvin Harrison Jr. is set to miss the upcoming face-off with the San Francisco 49ers. Harrison, who underwent appendicitis surgery this week, has been ruled out for Sunday's game, leaving the team scrambling to adjust their offensive strategy. FOX 10 Phoenix reported the young receiver's status update after Arizona's head coach, Jonathan Gannon, broke the news to the press, explaining, "Marvin, two nights ago, or one night… two nights ago, had surgery – appendicitis – so he's going to be out."

As the Cardinals prepare to host the 49ers on November 16 at State Farm Stadium, the focus shifts to how the team will cope without its leading receiver. Harrison Jr.'s season statistics stand at 34 catches for 525 yards and four touchdowns, significant numbers for an Arizona squad that's been clawing for victories. In a recent interview, quarterback Jacoby Brissett expressed his confidence in Harrison, noting the receiver's ability: "He's big, he's fast, can catch, he's tough. He wants the ball in those situations," Brissett told The Big Lead.

With Harrison Jr. recovering, the Cardinals' already depleted receiver lineup faces more challenges. Zay Jones is out for the season with an Achilles injury, Simi Fehoko is on injured reserve with a wrist issue, and the reality that Michael Wilson, Greg Dortch, and Xavier Weaver now need to step up is evident. NFL Network's Ian Rapoport has suggested that Harrison's timeline for return is uncertain and that he could potentially miss additional games, depending on the speed of his recovery.

The 49ers' defense, which has been formidable this season, will undoubtedly put pressure on the Cardinals' offense, which had a rough showing with a 35-0 deficit in the first half against Seattle. Coach Gannon emphasized the team's need to move past last week's loss, stating, "We’ll see," when asked if Harrison might be out longer, and, "Yeah, that’s life. That’s life in the NFL. It’s our job to put a plan together, get our guys ready to go," as reported by The Big Lead. The Cardinals are looking for redoubled efforts and focus as they navigate through the remainder of the season without one of their star players.