Genetic testing stalwart 23andMe is quietly shrinking its Silicon Valley footprint, shifting its headquarters into a far smaller office in Palo Alto. The move is the latest step in a multi-year retreat from the company’s once sprawling real estate portfolio after a run of financial turbulence and operational shakeups. Neighbors and office-market watchers can expect a slimmer, less flashy corporate presence as the firm pulls more of its operations under one roof.
According to CoStar, 23andMe plans to take space at 2555 Park Blvd. in Palo Alto, a location that represents a dramatic downsize from the large Sunnyvale campus the company once leased. The deal is framed as another move to clean up long-term office commitments after several rocky years.
Federal records also point to the Palo Alto address. The U.S. Food and Drug Administration's establishment registration now lists 23andMe Genomics LLC at 2555 Park Blvd., confirming the Palo Alto site as the company’s official location in agency filings that track device and establishment records, according to the FDA.
Before this pivot, 23andMe occupied a much larger lease in Sunnyvale, covering roughly 154,987 square feet at 223 N. Mathilda Ave., according to the company’s public filings with the SEC. That Sunnyvale building has since been picked up by new tenants, a change regional real estate outlets have tracked, including The Real Deal.
The real estate shuffle follows a bruising period for the company. In late 2024, 23andMe announced a broad restructuring with significant workforce reductions and cost cuts, as detailed in a corporate update from 23andMe. By March 2025, the firm had entered Chapter 11 bankruptcy while it pursued a sale of assets, a process covered extensively by TechCrunch and other tech media.
Palo Alto Property And Size
The Palo Alto building at 2555 Park Blvd. clocks in at roughly 30,000 square feet and is listed as a 2018-built, modern office that is essentially move-in ready, according to commercial property records from PropertyShark. Additional specs and amenities, including how the space is positioned to tenants, are detailed in the developer’s portfolio from Kenson Ventures, which highlight just how modest this office is compared with the company’s former Sunnyvale spread.
Industry coverage suggests the relocation fits neatly into a wider Bay Area pattern. A growing roster of tech and enterprise companies are trimming super-sized suburban campuses in favor of smaller, better-situated offices as hybrid work refuses to fade and landlords are forced to reprice space, trends that market reporters have chronicled in recent months, including Bisnow.
For landlords, brokers, and anyone keeping score on the regional office market, 23andMe’s downshift to 2555 Park Blvd. is another data point in a clear story. The age of huge, long-term footprints is giving way to smaller, more flexible setups, and even once high-flying brands are now living with far leaner square footage than they locked in during the late-2010s boom years.
