A three-car crash on the southbound 110 Freeway near Manchester Avenue left one person dead and four others hospitalized Monday night, triggering a lane shutdown in the heart of South Los Angeles. The Los Angeles Fire Department responded to the collision at 8:12 p.m. in the Broadway-Manchester area, within Los Angeles City Council District 15.
According to the Los Angeles Fire Department, firefighters from Fire Station 64 responded under Battalion 13 and found one person who was determined beyond medical help and pronounced dead at the scene. Four other patients were transported to local hospitals, the department said. The California Highway Patrol logged the crash as CHP Log 2528, and LAFD tracked it internally as Incident 1712.
The crash unfolded in the LAFD's South Bureau coverage area, and the southbound lanes of the 110 were impacted as crews worked the scene. It is not yet known whether speed, a sudden lane change, or impairment contributed to the collision — a detail that would typically emerge from a completed CHP investigation.
A Notoriously Dangerous Stretch of Freeway
Monday's fatal crash adds to a troubling record for this exact stretch of the Harbor Freeway. Northbound Interstate 110 at Manchester Avenue ranked as the sixth-highest crash location among Los Angeles freeway intersections, logging 158 collisions during an 11-month study period, according to an analysis published by Arash Law. The corridor's heavy commuter volume, rapid lane transitions, and frequent congestion near South LA off-ramps have made it one of the county's most crash-prone interchanges.
The area has seen multiple fatal incidents in recent years. On December 22, 2024, a 23-year-old man died on northbound I-110 near Manchester Avenue after a multi-vehicle crash forced him out of his vehicle and into traffic lanes, involving a sedan, a cargo van, and an out-of-service Metro bus, as reported by CBS LA. Less than two months earlier, on November 2, 2024, an overturned fuel tanker carrying 9,000 gallons of aviation fuel crushed a passenger car at the same interchange, fatally injuring its driver, according to LAFD alerts shared via Facebook; firefighters had to plug fuel breaches and transfer remaining aviation gas while Caltrans cleared up to 1,000 spilled gallons.
More recently, a four-vehicle collision near the Manchester Avenue off-ramp on March 21, 2026, led to the DUI arrest of an unlicensed 19-year-old driver with a 0.15% blood alcohol content, per traffic incident logs compiled by Golden State DUI. And on February 28, 2026, CHP fatal collision dispatch records show a multi-vehicle fatality on the southbound side of I-110 near Manchester Avenue that required officers to execute traffic breaks and shut down express lanes as stopped vehicles blocked center and slow lanes.
Surface Streets Face the Same Safety Reckoning
The freeway danger mirrors a broader safety crisis on the streets below. The Los Angeles Department of Transportation's Vision Zero initiative has designated South Broadway a priority safety corridor, identifying the intersection of Broadway and Manchester Avenue among the 25 most dangerous intersections in Los Angeles, Hoodline previously reported in coverage of a fatal hit-and-run involving a motorcyclist in the same neighborhood. Infrastructure improvements funded along South Broadway include pedestrian hybrid HAWK beacons intended to reduce severe crashes.
The Broadway-Manchester neighborhood itself covers 1.5 square miles bounded by Manchester Avenue and Interstate 110, and is home to more than 25,000 residents, according to Point2Homes demographic data — meaning high-density, multi-lane corridors cut directly through residential blocks surrounding the interchange. When lanes stay closed for 30 minutes or more due to an unplanned event, CHP protocol calls for a formal SigAlert, a designation established in Los Angeles in 1955 by radio pioneer Loyd Sigmon and distributed to media and freeway message boards, as explained by LAist.
A Citywide Pattern Driving Policy Change
LAPD data recorded 290 traffic collision deaths in Los Angeles in 2025, marking a second consecutive year of slight declines yet still keeping traffic fatalities higher than citywide homicides, per the same LAist report. That persistent gap has pushed city leaders toward new enforcement tools. In March 2026, the Los Angeles City Council voted 14-0 to authorize an automated speed safety pilot program installing up to 125 speed cameras across high-risk city corridors, according to legal analysis published by Arash Law, with the program enabled under state law SB 645 and ticketing scheduled to begin after public education periods later this year.
Monday's crash follows other recent fatal freeway incidents around the city, including a motorcyclist's death at the nearby 105/110 interchange in early August and a pedestrian killed by a pickup truck on the westbound 10 Freeway near downtown just days earlier this month. No further details on the identities of those killed or injured in Monday's crash, nor the cause under CHP's ongoing investigation, have been released.
