Missouri DHSS and the State Highway Patrol warned that ultra‑potent nitazenes are being detected in pills, vapes and powders. Officials posted step‑by‑step naloxone and rescue‑breathing guidance.

A St. Charles County pet sitter faces an animal-abuse charge after a Yorkie named Rosie died while her owners were on vacation; court video and a pathology report are central to the case.

Sensient will invest up to $250 million to expand natural food-color production in North St. Louis and is expected to add hundreds of jobs.

The Cardinals added a $29 Coca‑Cola Unlimited ticket in Big Mac Land and a rotating "made in the Lou" vendor series, plus new concessions across Busch Stadium.

A man was critically injured Sunday in a shooting on the 1100 block of S. 13th Street in St. Louis. Homicide detectives are investigating and police are asking for tips.

Progressive groups across Missouri are mobilizing around a proposal to phase out the state income tax, using the fight to build a longer-term statewide coalition.

Two men were killed and a third was hospitalized after a Saturday shooting in Carr Square; homicide detectives are investigating.

Round 12 of Monster Energy Supercross hits The Dome at America's Center on April 4 with FanFest, live racing and downtown impacts.

A federal jury in Springfield convicted Ahmaad Jarvis on fentanyl and meth charges after a traffic stop that reportedly turned up about 10 pounds of meth and 400 grams of fentanyl.

DEA agents in St. Louis seized nearly 600,000 fentanyl doses during a national Phase II sweep, along with meth, cocaine, guns and nearly $2M in suspected proceeds. The haul is part of the agency’s Fentanyl Free America campaign.

No‑excuse early voting begins next Tuesday in St. Charles County with vote centers at Element St. Charles and The Meadows Mall.

An 18-year-old was charged in connection with the October Carr Square shooting that killed 25-year-old Raykel Thompson.

RAC Chair Constantino Ochoa defended the commission after the Missouri auditor launched a spending review that could shift oversight to Explore St. Louis.