A Honolulu team used mRNA to produce PD‑L1‑blocking nanobodies that shrank colorectal tumors about 50% in mice, suggesting a cheaper alternative to pricey antibody drugs.

Warm, muggy and mostly cloudy in Honolulu with a slight chance of brief afternoon showers. Highs near 82–83°F and light east‑northeast winds.

Maui Health named COO Wade Ebersole interim CEO effective May 3 after Lynn Fulton announced she’ll return to Illinois. Ebersole will lead operations while the board searches for a permanent leader.

Sina Pili pleaded guilty to first-degree assault in the death of her 11-year-old adopted daughter. Sentencing is set for July 29.

Flooding from Waiawa Stream destroyed tents and gear at Agape Christian Fellowship, putting the 20th summer of Camp Agape — a free program for kids of incarcerated parents — at risk.

House Bill 2022 would cap Honolulu's vehicle weight fee at the state rate, cutting many registration bills by around 75% while prompting new reporting on road spending.

Kooks Coffee rolled a second cart into Kakaʻako while keeping its UH Mānoa trailer, serving playful drinks like Nanner Bread, Ubae Watch and plant-based Rockers.

Gov. Josh Green nominated Keith Amemiya and Marie Laderta to the University of Hawaiʻi Board of Regents. Their confirmations now head to the Hawaiʻi State Senate.

Istanbul Hawaii rolled out luxury spring dishes while Taco Rice opened a Kalākaua takeout window. Fancy French Cakes is taking online preorders for classic pastries.

Honolulu EMS data shows half of 36 recent Oʻahu bike incidents involved riders without helmets, with 20 people hospitalized. Advocates and agencies are pressing for proper fit and helmet access.

A Hawi man faces attempted murder and related felony charges after a grand jury indictment and an arrest, police say. Authorities are asking for tips.

Hawaiʻi DOH issued a brown water advisory for a stretch of West Maui shoreline; Launiupoko Beach Park is temporarily closed and officials warn against murky water.

Hawaiʻi DOH warned Tuesday that brown, murky water at Kamaʻole 2 Beach Park in South Maui may be contaminated; beach users are advised to avoid contact while conditions persist.