Scripps Research chemists reworked fentanyl's core to keep pain relief while cutting respiratory danger in mice, offering a possible blueprint for safer opioids.

Fire crews responded Friday to a residential blaze in the 2500 block of Los Alisos Drive in Fallbrook. Officials have not yet released details about injuries or damage.

Camp Pendleton scheduled live‑fire mortars and artillery March 21–29; loud booms could be heard across North County and beyond. The base posted a one‑page schedule and contact numbers.

Two adults and a juvenile were arrested after an Oct. 12, 2025 robbery at the Massachusetts Avenue Transit Center; deputies recovered a handgun during a La Mesa search.

Padres fans will find new curry, braided pretzels, savory pies and a braised short‑rib sandwich at Petco Park when the team opens next Thursday. Several local vendors and a renovated Stone Brewing bar are part of the new lineup.

A pedestrian was struck in the 4600 block of Pacific Highway near Old Town, leaving him unconscious and prompting a full road closure and police investigation.

Chula Vista police completed 143 compliance checks in a one‑day audit; 100 were confirmed compliant and 43 need follow‑up, officials said.

San Diego's water wholesaler approved a 21-year sale of surplus water to Riverside's Western Municipal Water District, locking in millions and a new model for trades.

A jury convicted Andrew Cardona Gomez of second‑degree murder in the 2025 Kunkel Park shooting that killed Anthony Trujillo. Sentencing is set for April 16, 2026.

Dominique Daniels Jr.'s scoring run carried Cal Baptist to its first NCAA Tournament and a first‑round date with Kansas. The WAC Player of the Year has become a national story.

San Diego‑based amphibious assault ship USS Boxer sailed Thursday to join U.S. operations in the Middle East, with local media and ship‑spotters documenting the departure.

San Diego police responded to a late‑afternoon call in Rolando Park; homicide detectives have taken over the scene on the 3800 block of Loma Alta Drive. Officials have released few details as investigators process the scene.

Kristina Saffran parlayed her recovery into Equip, a virtual eating‑disorder company now valued near $900M — a rapid expansion that spotlights both access gains and clinical limits.