On Saturday, an 85-year-old woman was struck by a vehicle in the intersection of 6th and Mission streets. The incident occurred at 4:55 p.m.
The woman suffered life-threatening injuries and was transported to a hospital, police said.
The driver, a 47-year-old man, fled the scene in his vehicle, but was later located by police officers and arrested.
The intersection of 6th and Mission streets has been identified as a high-injury corridor under the city's Vision Zero plan, which aims to eliminate traffic fatalities by 2024.
Earlier this month, a 27-year-old man also suffered life-threatening injuries in another SoMa hit-and-run collision, at 7th and Natoma streets.
Back in September, Modesto Figuerido, 61, was killed by a drunk driver while walking near the intersection of 9th and Howard streets.
And in March, two people suffered life-threatening injuries in separate hit-and-run collisions in SoMa.
Anyone who has information about either of these incidents is encouraged to contact SFPD via the department's anonymous tip line at 415-575-4444, or text TIP411 with "SFPD" at the start of the message.