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Published on November 19, 2023
Harvard Study May Reveal Genetic Mechanisms that Cause Sterility in Hybrid AnimalsSource: Wikipedia / jo9ce4line0
Liger (Tiger-Lion Hybrid)

Recent research offers insight into genetic mechanisms behind sterility in hybrid animals. Findings revealed that hybrid sterility aligns with Haldane's Rule, which states that the fertility of these hybrids is more impacted when they inherit differing sex chromosomes. This imbalance can lead to health complications or sterility. Butterfly genetics were used to explore this concept, according to Harvard Gazette.

In creating hybrid crosses of Papilio swallowtail butterflies species, they uncovered factors contributing to hybrid issues, such as low pupal weight and ovary malformations in females. These issues were traced back to an uneven mix of Z sex chromosome and other chromosomes, suggesting numerous genes maintaining balance within each species. The W chromosome in female butterflies, with minimal genes, does not significantly affect hybrid sterility.

The team discovered a pattern with female hybrids in another butterfly species, Heliconius, as studied by Neil Rosser and colleagues. Xiong expressed that answer was "more mathematical than expected, and that a very large number of genes actually explain the pattern better."

The study's analysis indicates that hybrid sterility could be polygenic, involving multiple genes, akin to human height. Mallet affirmed Xiong's discovery, saying it was the "fraction of the Z chromosome that matters."

The research provides valuable insight into hybrid sterility, which, in turn to can aid understanding of speciation, when different biological lineages diverge. Since different species often interbreed to produce viable but sterile offspring, this insight into genetics is not only key for understanding this natural phenomenon but also exploring speciation and the evolution of differing biological lineages.

Moving forward, the full picture of the genetic mechanisms behind hybrid sterility will require ongoing studies of hybrid crosses and identification of specific genetic factors involved. With continued research, scientist to can leverage this knowledge for developing strategies to help maintain healthy hybrid populations, thereby aiding their long-term survival in an evolving natural world.

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