Downtown San Francisco just landed another big AI player in its skyline. Zyphra, a startup chasing artificial general intelligence, has quietly moved into the entire 44th floor of Salesforce Tower, giving the still-young lab one of the most visible office addresses in the city and adding fresh AI energy to a trophy high-rise.
According to the San Francisco Business Times, Zyphra relocated from Palo Alto in January and subleased the full 44th floor at 415 Mission Street. The space is slated for research, engineering and expanded operations, putting the core of the company’s work squarely in the Financial District.
On its own site, Zyphra lists its headquarters as “415 Mission St, Floor 44” and describes itself as a full-stack, open-source AGI lab building foundation models and a general-purpose agent named Maia. The company has been publishing technical papers and model releases in recent months, which suggests the new floor will likely combine dense compute infrastructure with in-person research teams under one roof.
Funding And Hardware Partners
Zyphra has been scaling its training muscle through outside partnerships and growth-stage capital. In a release from AMD, the chipmaker outlines a collaboration in which Zyphra works with AMD and IBM to deploy MI300X-based clusters on IBM Cloud. That is the kind of hardware footprint that makes a dedicated lab floor in a high-rise a lot easier to justify.
Why The 44th Floor
The 44th story sits in the building’s marketed “Sky” levels, pitched as turnkey, high-quality office space with sweeping views and modern building systems. Leasing materials for Salesforce Tower tout those upper floors as a fit for technology and professional tenants that want prestige along with reliable infrastructure, which tracks neatly with what an AGI lab is likely looking for.
What It Signals For Downtown San Francisco
Zyphra’s full-floor sublease arrives as AI firms continue to drive a big share of San Francisco’s limited office rebound. As Bisnow has reported, AI tenants accounted for a substantial portion of 2025 leasing and helped concentrate demand in top-tier towers like Salesforce Tower.
The company is actively pushing out research and recruiting updates, hinting that its Salesforce Tower perch will function as a mix of lab space, product development hub and collaboration zone.
