St. Louis

Overnight Horror On I-44: Two Killed Near Manchester Road In St. Louis County

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Published on July 17, 2026
Overnight Horror On I-44: Two Killed Near Manchester Road In St. Louis CountySource: Google Street View

Two people were killed early July 12, 2024, when vehicles crashed on eastbound Interstate 44 near Route 100 (Manchester Road) in St. Louis County. Troopers were called to the scene at about 1:45 a.m., and one other person was taken to a hospital with injuries that were not immediately known.

State troopers shut down the eastbound lanes for several hours while they worked the scene and cleared wreckage. According to KSDK, the Missouri State Highway Patrol reported two fatalities and said an investigation was underway.

Investigation and Road Impacts

Per the Missouri State Highway Patrol, troopers are the lead agency on the probe and routinely close lanes so they can document serious crash scenes and remove damaged vehicles. Authorities have not released additional details about what caused the collision as the investigation continues.

I-44 Safety and Local Work

The deadly crash comes amid ongoing attention to safety and repairs along I-44. Planning work by MoDOT under its Forward 44 effort, along with resurfacing on nearby Route 100, is focused on addressing pavement, bridge and safety issues on stretches of the corridor.

Drivers in the area can expect occasional lane closures tied to both crash investigations and construction and are urged to slow down and move over for first responders. Anyone who witnessed the crash or has video is asked to contact the Missouri State Highway Patrol or local law enforcement with tips.