U.S. Customs and Border Protection officials seized more than 100 pounds of fentanyl during a search at the border crossing between San Diego and Tijuana, Mexico. Officers found the drugs hidden inside a 2018 Dodge Ram 700 that was attempting to cross into the United States.
The vehicle was stopped and searched by CBP officers at the Port of San Ysidro, according to KTLA. Inside, officers discovered more than 92 pounds of blue fentanyl pills, amounting to roughly 385,731 individual pills, along with more than 30 pounds of white fentanyl powder, an amount the agency says is equivalent to more than 1 million additional pills.
The CBP Office of Field Operations described the bust as a “massive narcotics interdiction,” the station reported, and said frontline personnel continue to focus on border security and protection against deadly synthetic drugs. Combined, the pills and powder recovered from the truck represent about 1.4 million potential doses of the synthetic opioid, which has driven overdose deaths across the country in recent years.
San Ysidro Has Seen a String of Major Busts
This is not the first eye-popping fentanyl seizure at San Ysidro in recent months. Last month, CBP officers at the same port of entry seized over 98 pounds of fentanyl and 36 pounds of cocaine from a single vehicle, a seizure Hoodline covered at the time. In April, officers at the same crossing seized nearly $2.8 million worth of fentanyl and methamphetamine across two separate stops, according to a release from U.S. Customs and Border Protection.
Other San Ysidro cases on record include a discovery of 25.66 pounds of white fentanyl powder and nearly 59 pounds of cocaine hidden in non-factory metal compartments built into a pickup truck's seats, per a separate CBP release.
Ports of Entry Remain the Main Chokepoint
Nationally, the pattern holds: most fentanyl entering the country is being caught at legal crossings rather than between them. Between January and August 2026, USAFacts data show fentanyl seizures were primarily at official ports of entry along the Southwest border.
USAFacts' analysis covers fentanyl seizures at U.S. borders from January through August 2026. Monthly totals can swing sharply, though; August 2026 alone saw about 773 pounds seized, a 24% drop from July. The U.S. Attorney's Office for the Southern District of California has previously said that fentanyl seizures in San Diego spiked roughly 323% from fiscal year 2019 to fiscal year 2021, rising from 1,599 pounds to 6,767 pounds, part of what prosecutors have called the city's emergence as a national epicenter for fentanyl trafficking.
CBP notes that its seizure statistics are subject to revision due to corrections, system changes, or additional information that comes in after an initial report. No arrest, suspect, or criminal charge connected to this particular seizure had been disclosed as of publication.
