A DUI-caused wrong-way collision on CA-163 in San Diego resulted in five severe injuries and significant traffic disruption. The incident involved emergency extrications and was classified as a Mass Casualty Incident.

A U.S. Navy MH-60R Sea Hawk helicopter crashed into San Diego Bay during training. All six crew members were rescued in stable condition. Investigations into the crash are ongoing.

Police in San Diego arrested three juveniles and an adult after tracking a stolen vehicle with GPS, leading to firearm charges and the recovery of handguns, including a ghost gun.

A man was killed by a Coaster train in Sorrento Valley, prompting an investigation led by the Sheriff's Transit Enforcement Unit. The incident occurred early Thursday morning.

Authorities offer a $15,000 reward for information on the 2021 murder of Navy sailor Cornelius Donte Brown in La Mesa, with his family contributing $9,000 to the sum.

Burglars were scared off by an alarm during a break-in in Chula Vista. Police seek help identifying them using released footage and encourage tips via Crime Stoppers or the P3 Tips app.

A suspected DUI driver led deputies on a high-speed chase, ending in a crash involving multiple vehicles and minor injuries, resulting in his arrest for DUI and related charges.

A sexually violent predator, Alan Earl James, may be released to Campo as San Diego Court orders his conditional release and proposes his placement at a local address, with a hearing set for community input.

Breeze Airways introduces five new nonstop routes from San Diego International Airport, starting as low as $59 one-way, with a promotional discount available until January 12.

A fire on the 4th floor of a high-rise on 14th Street prompted evacuations and a third-alarm call. Sprinklers extinguished the flames, resulting in no fatalities but $150,000 in damages. An accidental lithium-ion battery fire is cited as the cause.

Johnson & Johnson is set to acquire Ambrx Biopharma for $2 billion to enhance its cancer treatment portfolio, particularly in advanced antibody drug conjugates.

San Diego Zoo Wildlife Alliance collaborates with Illumina to sequence the DNA of North American koalas, focusing on combating diseases such as Koala Retrovirus (KoRV).

A tragic accident on State Route 94 claimed the life of a young motorcycle rider, Jadahn Schaefer, 27, of Lemon Grove...