San Diego Firefighters tackle a 2nd alarm fire in the heart of downtown.

As Stefan Lowry's disappearance reaches its second day, families in Orange and LA counties feel the growing tension as authorities call on residents for help in locating him.

Following a stabbing incident near a Gaslamp Quarter nightclub in San Diego, the suspected attacker - a 21-year-old man - has been arrested by the San Diego Police Department during the early hours of Monday morning.

A deadly DUI crash near Ramona leads to the closure of State Route 67, leaving one person dead and stirring questions about safety on the road.

A road rage incident turned violent as a stabbing takes place in Carlsbad, leaving a victim with non-life-threatening injuries.

A 29-year-old man sustains a face injury but narrowly escapes a terrifying shooting incident at a Lincoln Park apartment complex in San Diego.

DUI checkpoint leads to 3 Arrests - Escondido PD will have an upcoming checkpoint in December.

A 63-year-old pedestrian is left in critical condition after an elusive driver leaves her fighting for her life in a hit-and-run accident at a San Diego Costco.

A U.S. Postal Service employee in San Diego is accused of violently assaulting his supervisor, carrying out an act that echoes past instances of workplace aggression within the agency.

San Diego law enforcement's "Operation Sunrise" reveals the complex, dangerous network of auto theft rings. Dozens arrested, firearms and drugs seized in an effort to protect communities from a growing crisis.

A chilling murder-for-hire plot in San Diego County ends with the arrest of the alleged mastermind, a woman with the sinister plan to have her husband killed.

A recent controversy involving San Diego Unified School District's name and gender form encourages students to identify as trans or nonbinary while keeping their parents uninformed.

A man was brutally killed in a crowded McDonald's parking lot, with the attacker fleeing the scene in a chilling minivan getaway.