Scripps Research chemists reworked fentanyl's core to keep pain relief while cutting respiratory danger in mice, offering a possible blueprint for safer opioids.

Fire crews responded Friday to a residential blaze in the 2500 block of Los Alisos Drive in Fallbrook. Officials have not yet released details about injuries or damage.

San Diego's water wholesaler approved a 21-year sale of surplus water to Riverside's Western Municipal Water District, locking in millions and a new model for trades.

San Diego police responded to a late‑afternoon call in Rolando Park; homicide detectives have taken over the scene on the 3800 block of Loma Alta Drive. Officials have released few details as investigators process the scene.

A 2023 planning adoption error left parts of Barrio Logan labeled commercial and a Boston Avenue parcel was sold. City Council has voted to restore the land to park use.

San Diego reached a marketing deal with Hyundai to supply 32 lifeguard vehicles, transfer maintenance to Hyundai and gain marketing support in a package the city values at about $4M.

A draft assessment says Encinitas faces millions in repairs to City Hall, parks and community buildings.

Kimberly J. “Kim” Becker is retiring after 40 years leading SAN through record growth and the New Terminal 1 project, and Mayor Todd Gloria publicly thanked her. Atif Saeed will take over as the airport’s new CEO.

A Mount Hope father suffered severe burns shielding his 2-year-old in a fast-moving house fire that destroyed the family's home.

A fatal shooting in Jamul ended with one person pronounced dead at an Alpine fire station. Sheriff's homicide detectives have detained a man and are asking for tips.

FBI San Diego posted a 12‑item wanted and missing roster on Wednesday, naming suspects and cold cases and asking the public to submit tips.

A second‑alarm fire tore through a three‑story Chollas Creek apartment Tuesday afternoon. Crews knocked the flames down quickly while officials said cause and injuries were unclear.

SDG&E warns real estate agents and homeowners about texts, calls and emails impersonating utility workers that push victims to pay with crypto or prepaid cards.