Pfizer will vacate its 181 Oyster Point research site by the end of April, shifting staff to remote roles and putting much of the 164,000‑sq‑ft building up for sublease.

A San Jose Powerball ticket missed the $216M jackpot but matched four numbers plus the Powerball, paying $44,744 under California’s rules.

Barnes & Noble has filed plans for a 19,200‑sqft bookstore at 20740 Stevens Creek Blvd in Cupertino. The project, part of a national expansion, is under city review.

Neurocrine will pay $53 a share to buy Redwood City’s Soleno for about $2.9B, adding VYKAT XR — the first FDA‑approved treatment for hyperphagia in Prader‑Willi syndrome.

Amazon held a ribbon-cutting in Brisbane to launch Amazon Pharmacy and Same-Day prescription delivery for Bay Area customers.

A remote Big Sur station listed premium at $9.99 this week. Owner says generators and delivery costs drove the high price.

Intel tapped Zoom COO Aparna Bawa to run legal, compliance and people as the chipmaker reshuffles senior leadership. She’s expected to join in May to oversee legal and culture.

A UC Giannini analysis finds California lost roughly $1 billion in China sales after 2025 tariffs, with pistachios, almonds and wine among the biggest losers.

Suno quietly opened a SoMa office and is ramping local hiring as it expands its music‑AI engineering and product teams amid label disputes.

Here's a brief roundup of recent changes to Castro area businesses. In this edition, a new restaurant softly opens, a gift shop rebrands, a yoga studio nears opening, and construction continues at the former Harvey's space, though no tenant has yet been identified.

Intel will repurchase Apollo’s 49% stake in Fab 34 for $14.2 billion, a move the company says reflects a stronger balance sheet and rising AI demand.

A San Francisco chatbot startup says Apple pulled its apps and froze more than $500,000 in developer payouts; the company has filed suit asking a court to restore access and release funds.

The ITC has opened a Section 337 investigation after InnoTV Labs alleged Roku and Hisense infringe display‑technology patents. The complaint seeks import bans and other remedies.