Eli Lilly will buy Boston‑based Centessa for about $6.3B, adding an orexin agonist program led by cleminorexton. The deal pays $38 per ADS up front and could reach $47 with milestones.

Grocery Hub has opened at 1435 W. 86th St., taking over the former AIM Mart and bringing halal butchers, an in-house bakery and international aisles to northwest Indianapolis.

Small Hoosier towns say brown tap water keeps appearing in faucets while state funding and aging pipes leave costly system fixes out of reach.

The Colts say they haven't found a trade partner for Anthony Richardson while Daniel Jones is the team's starter. Releasing Richardson would cost roughly $5.4M in dead money.

Gusty southwest winds will push highs near 79 today with showers likely late; heavy rain tonight could spark minor river and urban flooding in spots.

Fire crews extinguished a double-house blaze on Indianapolis’ near east side early Monday — neighbors say it’s the fourth response to those vacant properties in 90 days. Investigators are probing the cause.

Clear will add paid biometric lanes at Indianapolis International Airport this summer, promising faster ID checks for members and a modest boost in local jobs. The airport authority approved the deal in late March.

South Carolina's Vicious Biscuit has opened in Fishers, bringing big biscuits, a jam bar and plans for ten Indiana locations.

The Marion County Sheriff’s Office is asking for help finding 33‑year‑old Ronald R. Dillow, a sexually violent predator wanted for failing to register. Tips can be submitted anonymously.

A Noblesville High School freshman has asked the U.S. Supreme Court to decide whether schools may ban student flyers with political slogans. The petition challenges a Seventh Circuit ruling that sided with the district.

An Indianapolis mother and her boyfriend face child‑neglect charges after a 4‑year‑old special‑needs boy was found unresponsive. Court records allege he had been forced to sleep in a basement closet.

Braylon Mullins hit a 40-foot, buzzer-beating three with 0.4 seconds left to lift UConn past Duke 73-72 and send the Huskies to the Final Four in Indianapolis.

Councilors and residents say a state-backed water program tied to the LEAP district could put Eagle Creek Park at risk, citing treated wastewater plans and transparency gaps. They want stronger guarantees before Indianapolis stays involved.