San Diego Mayor Todd Gloria was installed as president of the U.S. Conference of Mayors and pledged to press Washington on housing, safety and accountability.

Avenzo will go public via a reverse merger with Rallybio, backed by a $215M financing and expected to trade as AVZO. The deal funds multiple clinical readouts through 2028.

A competitor in the SCORE Baja 500 died Saturday after a crash near Race Mile 324 in Ensenada. SCORE and local officials say the incident remains under investigation.

Little Fawn debuts inside the Fin Hotel with shareable California‑Mediterranean plates, natural wines and a tight cocktail program.

La Jolla Institute researchers joined a PNAS study that introduced "superHLA," a computational pipeline that scanned more than 190,000 peptides and validated 24 superbinders. The method could help identify vaccine targets that work across diverse genetic backgrounds.

A 62-year-old woman died after being struck on El Cajon Boulevard near Hamilton Street Friday night. San Diego police say their Traffic Division is investigating.

AB 2222 would create refundable per‑reporter tax credits in California, aiming to shore up thousands of local newsroom jobs while raising cost and oversight questions.

A brief Pacific Beach pursuit ended when a Mercedes struck another car on Garnet Avenue, leaving a passenger with multiple fractured vertebrae. Police arrested a 39-year-old man on suspicion of felony DUI causing injury and evading.

National City approved an $89.1M general‑fund budget this week that narrows the projected gap but leaves unassigned reserves under pressure. Officials promise tougher choices and revenue work ahead.

Cloudy morning in San Diego with mid-60s now and highs near 71°F. Coastal fog lingers; warming into the mid‑70s by midweek.

Three people were hospitalized after a stabbing at San Clemente Pier Saturday night; deputies say one person was detained and the incident appeared gang-related.

The San Diego medical examiner lists acute fentanyl toxicity and records Nadine Jett’s death as a homicide, according to a death certificate obtained by local reporters.

UC San Diego researchers developed a non‑destructive “milking” method to extract therapeutic plant particles under simulated space stressors, pointing to on‑demand medicines for long missions.