Central Drug Store in San Francisco's Excelsior is closing after 116 years. Owner Jerry Tonelli is retiring, ending the store's multi-generational service to the community.

Here's a brief roundup of recent changes to Castro area businesses. In this edition, a plant shop shutters, a small group fitness studio expands, and a restaurant adjusts its hours.

Japan Video, a cultural staple in San Francisco's Japantown for over 38 years, is closing down in May. The store was known for its Japanese and Korean video collection and anime merchandise.

Regeneron Pharmaceuticals is acquiring the assets of 23andMe for $256 million, excluding its Lemonaid Health business, as the company faces layoffs and office closure due to financial struggles and a past cyberattack.

San Francisco's Union Square welcomes a new Nintendo flagship store, providing an immersive retail experience with exclusive merchandise and a custom gaming zone.

California is now the world's fourth largest economy, surpassing Japan, with a GDP of $4.1 trillion. Governor Newsom attributes this to investments in people and innovation but warns that Trump's tariff measures could harm growth.

Goodwill San Francisco Bay is closing 11 locations and its headquarters after merging with other chapters, citing financial sustainability goals. This leads to layoffs and concerns about service disruptions for veterans and other clients.

Apple airlifted iPhones from India to the US to avoid tariffs on Chinese goods, shipping an estimated 1.5 million units amid fears of significant price hikes due to the trade war.

San Francisco's Off the Grid night market is set to return to Fort Mason with over 25 food vendors, 100 local retail shops, and live entertainment starting April 18.

Goodwill San Francisco Bay confirms closing an Oakland store and a San Francisco career center, leading to 90 layoffs. The closures are part of a strategic reorganization.

Zara is set to relocate to a new flagship store in Union Square, San Francisco, reflective of confidence in the area's retail future, amid a struggling market and efforts to enhance local commerce.

Redwood Materials opens a new R&D center in San Francisco to expand its team and advance its work in battery recycling, refining, and remanufacturing.

Here's a brief roundup of recent changes to Castro area businesses. In this edition, a Chinese restaurant has closed, and a matcha shop, Japanese hot pot restaurant, and dental office have opened.