St. Louis County officials say medetomidine — called "rhino tranq" — has been detected in local street drugs, and its sedative effects may not be reversed by naloxone alone.

Two armed suspects robbed the Isle of Capri Casino in Boonville; the getaway car was later found abandoned in Howard County. Investigators are searching for the pair.

The Missouri attorney general sent 33 cease-and-desist letters Wednesday — 18 in St. Louis — after tests found heavy metals and mislabeled THC products at unlicensed shops.

After nearly a year back as interim, Otis Williams is retiring from SLDC and pressing banks and city leaders to make redevelopment financing more predictable. He says local lenders must return if projects are to move forward.

A Cool Valley standoff ended with a woman arrested after a reported stabbing; the victim was hospitalized with life-threatening injuries.

Porano’s Des Peres outpost will close March 31 as Niche Food Group pauses expansion and refocuses on existing restaurants.

Jurors heard racist social-media posts from a St. Louis officer — including the slur "ghetto cockroach" — in a trial over the 2016 shooting of a 14-year-old.

St. Louis will top out near 92°F Thursday before a late-night line of storms. Gusty southwest winds and a hail risk are possible overnight.

The 8th U.S. Circuit upheld a policy that bars bond hearings for many immigrants arrested in interior operations; civil‑rights groups are preparing appeals.

Charges were filed this week after a robbery attempt in Florissant ended in a fatal shooting, authorities say. The suspect is in St. Louis County jail.

A child was critically injured Tuesday afternoon in a shooting near Broadway and Humboldt in north St. Louis. Police are investigating and asking witnesses to come forward.

County filings and developer materials show Target will anchor Farmington Crossings, a new 316,000‑sq‑ft retail center at Hwy 67 and Woodlawn Drive.

Missouri DHSS and the State Highway Patrol warned that ultra‑potent nitazenes are being detected in pills, vapes and powders. Officials posted step‑by‑step naloxone and rescue‑breathing guidance.