ENCORE Research Group is enrolling in Jacksonville for an early trial testing a potential one‑time gene‑editing treatment that aims to permanently lower LDL for people with inherited high cholesterol.

A Jacksonville electrical contractor bought a one‑acre site in Lackawanna and will expand its headquarters to about 20,000 square feet to support a growing team and a new climate‑services arm.

Franchise veterans are opening Boost Coffee & Energy this spring — a compact dual‑lane drive‑thru that pairs fresh‑roasted coffee with cleaner energy drinks.

A local coalition says Mayor Donna Deegan’s Eastside board picks give LIFT JAX too much influence over $40M in community benefits funds. City and council leaders say nominees will be vetted before any money is awarded.

Local restaurateurs Jeff McCusker and Bob Fleckenstein filed permits to convert the former Ragtime site at 299 Atlantic Blvd into Grafton & Fleck’s Steakhouse with rooftop seating.

A Jacksonville Beach man was arrested after a North Florida ICAC investigation that began with a tip to NCMEC. Police executed a search warrant and say forensic review is ongoing.

A 23-year-old man died after his sedan left SR 26, struck a sign and trees and overturned near SR 21 in Putnam County. The Florida Highway Patrol says the crash is under investigation.

A 1913 Jacksonville warehouse was converted into 228 apartments and mixed‑use spaces and has won a 2026 CoStar Impact Award, highlighting preservation‑led development on the Eastside.

A Clay County couple pleaded guilty after investigators say a man posed as a nurse while caring for a retired Marine; state records and surveillance footage were central to the probe.

Hamburger Mary's Jax 2.0 says eviction proceedings could start this week and asks supporters to donate, while warning that scammers are copying its Venmo handle.

Homicide detectives were on Edgewood Avenue West near I‑95 in Lake Forest Sunday night; officials expected a briefing and are asking witnesses to come forward.

A 19-year-old St. Augustine woman died after her car left State Road 206 Sunday night; troopers say she was ejected and was not wearing a seatbelt.

A 64-year-old man and a 61-year-old woman from Lake City were killed after their motorcycle struck a boat being towed on U.S. 27 west of Mayo; the Florida Highway Patrol is investigating.