CBP officers in San Diego seized over $40,000 worth of drugs from two vehicles at the San Ysidro Port of Entry, arresting two men in separate incidents.

San Diego's Best Veterinary Care settled for $125,000 over allegations of mishandled controlled substances, following a DEA investigation into improper records and inventory.

A historic Alpine home was destroyed by fire, displacing a pastor and his extended family. No casualties were reported, but the house, significant to the local community, is a total loss.

Carlsbad police arrested two individuals on probation for multiple offenses after finding drugs, stolen mail, burglary tools, and a disguised knife during a routine patrol car search.

Marquella Marshall and Marsha Delacruz were sentenced in federal court for participating in a San Diego drug distribution network linked to the Mexican Mafia.

The acting world is mourning the loss of one of its own as Alec Musser, the actor best known for his stint on "All My Children," was found dea...

A man was fatally struck by an Amtrak train near Carlsbad Village Station. The Sheriff's Transit Enforcement Unit is investigating the incident, with the Medical Examiner's Office determining the cause of death.

A 4.4-magnitude earthquake struck off the Southern California coast, felt by residents from San Diego to Long Beach with no damage reported.

A woman was arrested after a suspected arson at an El Cajon apartment complex that destroyed 14 garages. Mavis Williams was caught following a tip; she now faces charges for recklessly causing a fire.

A woman faces DUI charges after a fatal pileup on I-5 in Carlsbad, which resulted in two deaths and major injuries.

A man was struck and killed by a train in Encinitas, with a Sheriff's Transit Enforcement Unit investigation underway. The victim's identity is pending notification of next of kin.

Raul Flores Hernandez was sentenced to nearly 22 years in prison and ordered to forfeit $280 million for running a major cocaine distribution network linked to the Sinaloa Cartel.

A former U.S. Navy doctor was sentenced to just over a year behind bars for defrauding the government out of $2 million, officials said. Dr...