Neurocrine will pay $53 a share to buy Redwood City’s Soleno for about $2.9B, adding VYKAT XR — the first FDA‑approved treatment for hyperphagia in Prader‑Willi syndrome.

A Chula Vista realtor's viral video shows an alleged squatter living in a home she purchased; eviction took nearly 10 months amid a court backlog.

Trump on April 6 gave Steve Hilton a high‑profile endorsement on Truth Social, injecting national energy into a chaotic California primary. The nod could change who advances from the June 2 top‑two vote.

A vegetation fire in San Marcos on Sunday pushed residents and part of the Cal State San Marcos campus to evacuate as local and state crews and aircraft worked containment.

Morning fog along the coast, sunny afternoons in the low 70s. Rain chances grow late in the week with the heaviest showers expected Saturday.

AES pulled the contested "Seguro" battery-storage plan near Escondido after months of neighborhood opposition and new county safety scrutiny. The 22–23 acre site's future is now uncertain.

Alwin "Ben" Holman, who integrated San Diego firehouses in 1951 and rose to deputy chief, has died at 100.

Patchy fog this morning clears to mostly sunny skies with highs near 76°F. A cooler, breezier stretch and light-showers chance arrives April 9–11.

Tori Spelling and several children were treated at hospitals after a two‑car crash in Temecula on Thursday; deputies say the collision is under investigation.

Pepper Park reopened Saturday after an $8M Phase One renovation, unveiling a splash pad, pirate playground and new bayfront terraces. Families turned out in force for the celebration.

A head-on collision on SR‑78 near Julian killed two people and closed the highway in both directions while crews worked the scene.

Gaslamp merchants say unlicensed carts are crowding sidewalks and undercutting storefronts. They want the city to publicly confirm enforcement as lawsuits and an appeals court ruling complicate policy.

EPA has quietly asked whether to exempt some plastic “advanced recycling” plants from Clean Air Act rules, a move that drew industry praise and activist alarm. A public hearing and comment period are now open.