Pivot Bio is investing more than $7 million to expand manufacturing in Hazelwood and will add 40 jobs while pairing production with Creve Coeur research.

An investigation found eight residents of Dismas House died of fentanyl overdoses between 2021 and 2023, and gaps between medical‑examiner findings and federal records raise oversight questions.

Sunny, breezy Wednesday with highs near 67°F. Gardeners in northern suburbs should watch for possible frost Saturday morning.

A prominent local lawyer has snapped up several starter homes on Corona Court, leaving neighbors worried about affordability and the neighborhood’s future. City leaders and a new land trust are weighing responses.

A former East St. Louis library director was sentenced to 15 months and ordered to repay $102,249 after prosecutors say she used library and replacement benefit cards for personal gain.

Centene posted a $1.5B quarter even as Marketplace enrollment fell by about two million after enhanced subsidies expired. Medicare drug plan growth and cash moves helped offset the hit.

A Missouri bill would require K‑5 districts to adopt screen‑time policies and create a state FOCUS council. Supporters say it’s a course correction; educators warn of equity risks.

Police released surveillance images after two women were robbed at gunpoint on Cherokee Street. Officers say the suspect was captured on video and tips to CrimeStoppers may be eligible for a reward.

A St. Louis man pleaded guilty and was placed on probation after the 2024 Ted Drewes parking‑lot crash that injured multiple people.

A St. Louis man was arrested after police say he robbed a Phillips 66 in Alton at gunpoint and then used a stolen car to try to break into a nearby business.

The city’s Land Clearance board voted to solicit demolition bids for the condemned garage beside the Railway Exchange and an adjacent vacant Charlie Gitto’s storefront, clearing a block for redevelopment.

Saint Louis University will immediately discontinue its men's and women's tennis programs, affecting 19 student‑athletes and eliminating coaching roles.

NWS survey crews confirmed an EF1 tornado near Mascoutah after Monday's storms; crews found snapped poles and damage near MidAmerica Airport.