Los Angeles firefighters mounted a sizable response Tuesday afternoon after smoke began pouring from the second floor of a building at 4325 S Main St in Historic South‑Central, turning the quiet stretch into a full‑blown fire scene.
According to LAFD, crews were dispatched at about 1:15 p.m., with the incident logged as INC#0961. The call described a four‑story "modern center hall" apartment building with smoke showing from the second floor and listed Station 46, Battalion 13, and multiple engine, truck, rescue, EMS, and hazardous‑materials units among the responders.
Public property and rental listings show 4325 S Main St contains multiple residential units, with one‑bedroom apartments marketed for rent in recent months, per Zillow. County parcel and commercial records list the address under APN 5111‑012‑030, indicating a mixed‑use property profile, per LoopNet.
LAFD ALERT- Historic South-Central Structure Fire 4325 S Main St MAP: https://t.co/CFVCiOwZIo FS46; DETAILS: https://t.co/lmTyWEzTkd
— LAFD (@LAFD) March 24, 2026
Response And On‑Scene Operations
In its initial alert, the department said "firefighters are in offensive mode" as crews worked to knock down the second‑floor fire, and placed the incident in City Council District 9, per LAFD. The long list of responding companies in the post underscores the size of the assignment, with multiple engine, truck, rescue, EMS, and hazmat units rolling on the call.
Historic South‑Central has seen a string of structure‑fire responses this winter; coverage of a pre‑dawn blaze on W. 43rd St on March 3 highlighted many of the same companies working in the neighborhood. Those repeated calls reflect the heavy workload for Battalion 13 and South Bureau crews as they tackle fires in older mixed‑use blocks.
For official updates and any evacuation notices, check the department's alerts feed and social channels; the LAFD alerts page is the primary source for real‑time notices. In emergencies, call 911 and follow directions from crews on scene.
We will update this story if the department releases additional information about injuries, the extent of damage, or an investigation into the cause. For now, neighbors are urged to avoid the immediate area and give firefighters room to operate while emergency personnel complete overhaul and safety checks.
