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The 39-year-old store was preparing to close after its owner offered the location for sale last fall.
The clinic offered services like acupuncture, massage, nutrition counseling and herbal therapies at affordable rates.
Shoppers will find a handful of independent shops offering fresh produce, sandwiches and dry goods.
To qualify, a business must have "existed for more than 30 years" and "show significant contribution to San Francisco's identity.
The store's lease is set to expire.
The new tenants will take over the mural on the building's Church Street frontage.
Instead of reverting back to a full café, the location will likely remain a retail space.
Both businesses have operated in San Francisco for more than 80 years.
During the day, vacant restaurants become shared work spaces.
The new liquor store was two years in the making.
Founder Gary Weiss has operated the unique floral shop from the same location for 34 years.
The bakery's current owner told Hoodline he wants people to know that his cakes will still be available.
Before opening, the shop's native French owners hosted pop-ups to build their brand and clientele.
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