Phil’s One Stop in Fort Wayne sold a $100,000 Powerball (with Power Play) ticket and Murphy’s USA in Plymouth sold a $50,000 ticket after Monday’s drawing. Winners should follow Hoosier Lottery claim steps.

Novo Nordisk will lay off roughly 400 workers at its Bloomington manufacturing site in early May, a cut that affects about one in five roles amid ongoing regulatory scrutiny. City officials say they will work to connect impacted employees with support and job resources.

A North Vernon man was jailed after a cyber tip led investigators to child sexual abuse material and videos allegedly showing sexual acts with a calf and the family dog. Authorities say the probe is ongoing and more charges may follow.

Court documents say a 19‑year‑old Carmel man had hundreds-to-thousands of alleged child sex abuse material files on devices; bond was set at $150,000. The case has pretrial dates this spring and a jury trial scheduled for August.

Eli Lilly will buy Boston‑based Centessa for about $6.3B, adding an orexin agonist program led by cleminorexton. The deal pays $38 per ADS up front and could reach $47 with milestones.

Grocery Hub has opened at 1435 W. 86th St., taking over the former AIM Mart and bringing halal butchers, an in-house bakery and international aisles to northwest Indianapolis.

Small Hoosier towns say brown tap water keeps appearing in faucets while state funding and aging pipes leave costly system fixes out of reach.

The Colts say they haven't found a trade partner for Anthony Richardson while Daniel Jones is the team's starter. Releasing Richardson would cost roughly $5.4M in dead money.

Gusty southwest winds will push highs near 79 today with showers likely late; heavy rain tonight could spark minor river and urban flooding in spots.

Fire crews extinguished a double-house blaze on Indianapolis’ near east side early Monday — neighbors say it’s the fourth response to those vacant properties in 90 days. Investigators are probing the cause.

Clear will add paid biometric lanes at Indianapolis International Airport this summer, promising faster ID checks for members and a modest boost in local jobs. The airport authority approved the deal in late March.

South Carolina's Vicious Biscuit has opened in Fishers, bringing big biscuits, a jam bar and plans for ten Indiana locations.

The Marion County Sheriff’s Office is asking for help finding 33‑year‑old Ronald R. Dillow, a sexually violent predator wanted for failing to register. Tips can be submitted anonymously.