San Diego’s cAMPfield closed a $180M Series A to advance prifemilast, a once‑daily oral PDE4B inhibitor, into global trials for IBD.

Biogen agreed to buy San Diego‑based RayThera for up to $1 billion, adding early‑stage immunology candidates and a lead program heading into Phase 1.

UC San Diego’s Moores Cancer Center won a five‑year NCI core grant renewal — roughly $25M — to speed trials, hire physicians and expand infusion capacity across San Diego.

A Parkfield study using machine learning found short slow‑slip events that boost low‑frequency quakes, prompting scientists to rethink how California's hazard models account for transient stress.

UC San Diego and Stanford researchers found brief electrical pulses rejuvenated sea squirts and raised questions about stem‑cell aging in people.

Tempo is setting up its corporate headquarters in San Diego as it pushes to commercialize thermochemical “thermal battery” systems for industrial electrification. The move is meant to speed pilots into commercial deployments.

Visa has embedded its payments network into ChatGPT, letting AI agents buy for users while banks and merchants raise fraud and fee questions. The shift moves agentic shopping from experiments toward network rails.

San Diego’s Autobahn secured FDA Fast Track for elunetirom and reported strong Phase 2 topline results in a small bipolar depression study. The findings are promising but preliminary.

SDG&E, Qualcomm and UC San Diego’s Scripps launched Edge Alert Sentinel — an on‑site AI pilot on Palomar Mountain to flag wildfire and extreme‑weather risks faster. The first unit will be evaluated during the PSPS season and could scale regionally in 2027.

Avenzo will go public via a reverse merger with Rallybio, backed by a $215M financing and expected to trade as AVZO. The deal funds multiple clinical readouts through 2028.

La Jolla Institute researchers joined a PNAS study that introduced "superHLA," a computational pipeline that scanned more than 190,000 peptides and validated 24 superbinders. The method could help identify vaccine targets that work across diverse genetic backgrounds.

UC San Diego researchers developed a non‑destructive “milking” method to extract therapeutic plant particles under simulated space stressors, pointing to on‑demand medicines for long missions.

UC San Diego researchers found SynCav1 preserved memory and neuron structure in mice with TDP‑43 pathology, suggesting a neuron‑focused path forward for dementia research.