Nopalito is the latest business to fall victim to the pandemic — but when one door closes, a window opens.

The former sandwich shop had revamped last year to become a Japanese rice bowl and sushi eatery.

Owned by her longtime friend Matt Leum, Roma's will offer classic Italian food in an inclusive, queer-friendly space.

Normally competitors, neighboring restaurants are now joining forces to convince the city to close down their streets for outdoor meals.

"It's not looking good for the restaurant business," says owner Juan Romo.

"We're going to step up the cocktail game of the Castro," says Hi Tops' Jesse Woodward of his forthcoming restaurant and cocktail bar.

SF bars need to sell to-go cocktails to stay afloat, but they're required to serve them with "bona fide" meals. For bars without kitchens, that's a challenge.

"For hospitality, there has never been a worse time," says Steve Izzo, who co-owned the restaurant with his wife, Lee Ann.

It's Tops' famed neon signage at Market and Octavia streets was removed on Wednesday.

In the works for over three years, the sizable new brewpub was further delayed by the pandemic.

San Franciscans will be allowed to eat at restaurants again starting Friday, but only outdoors and under strict rules.

After struggling to stay afloat for several months, married owners Tom Prabpan and Chin Han Yat have decided to close their restaurant.

"It was just time," says owner Jesse Fink of the decision to sell his legacy business, a Richmond District favorite.